HRS 2025 - Contemporary outcomes from implantable devices in non-ischemic cardiomyopathy patients observed more advanced heart failure symptoms in women at the time of ICD implantation, and white women implanted with CRT-D devices had significantly lower ventricular arrhythmia events compared to men of all races and black women implanted with both device types.

Dr Valentina Kutyifa (University of Rochester Medical Center, Rochester, US) joins us to discuss contemporary outcomes from the prospective BIO-LIBRA study (NCT03884608; Biotronik, Inc.), investigating data across the US on patients with non-ischemic cardiomyopathy implanted with ICD or CRT-D devices. 48% of the patient population were women, and the primary goals were to assess the effects of sex-based differences, mortality rate and ventricular arrhythmia event rate after device implantation.

Interview Questions:
1. What is the importance behind the BIO-LIBRA study?
2. What are the sex-related patient profile differences between non-ischemic cardiomyopathy patients?
3. What are your key findings and how can they help risk stratification?
4. Were there any surprising or unexpected results?
5. How should these findings impact clinical practice?
6. What further study is needed in this area and what are the next steps?

Recorded remotely from Rochester, 2025.

Editors: Jordan Rance, Yazmin Sadik
Videographers: David Ben-Harosh

Support: This is an independent interview produced by Arrhythmia Academy.