HRS Congress 2026 — Prof Elad Anter (Yitzhak Shamir Medical Center, Beer Yakov, IL) joins us to discuss findings from a study investigating reentry at patient-specific atrial regions characterised by steep repolarisation gradients as a mechanism of atrial fibrillation in humans.

Interview Questions:

1. What is the current state of debate around reentry as a mechanism of AF, and what has been missing from the evidence base?
2. What led you to focus on repolarisation gradients, and how do patient-specific anatomical regions factor into this?
3. What have you observed in humans, and what does this tell us about how AF is initiated and sustained?
4. How does this change the way we should think about AF as a disease — is it more heterogeneous and individualised than current models suggest?
5. What are the potential implications for ablation strategy if repolarisation gradients are confirmed as a key substrate?
6. Where does this line of work go next?

Recorded on-site at HRS Congress 2026, Chicago.
 

Editors: Jordan Rance
Videographer: Oliver Miles
Support: This is an independent interview produced by Radcliffe Cardiology.