EHRA 2026 — Prof Pier Lambiase (University College London, UK) joins us to examine the evolving landscape of VT mapping, exploring how advances in identifying arrhythmia drivers and delineating conduction channels are reshaping ablation strategy and outcomes in complex ventricular arrhythmia.

From the limitations of conventional substrate mapping to the growing role of high-density mapping systems and mechanistic insights into VT maintenance, Prof Lambiase offers an expert perspective on how these new strategies are translating from electrophysiology lab to improved patient outcomes.

Interview Questions:

1. How has our understanding of VT mechanisms evolved over recent years, and what has driven that shift?
2. What are the key limitations of conventional VT mapping approaches, and where do newer strategies offer the most meaningful improvement?
3. How are high-density mapping technologies changing the way we identify and target conduction channels in clinical practice?
4. What is the current evidence base for driver-guided ablation, and how confident are we in its reproducibility across different patient populations and disease substrates?
5. How do you approach VT mapping strategy in patients with non-ischaemic cardiomyopathy, where substrate characteristics differ significantly from ischaemic disease?
6. What are your key take-home messages for electrophysiologists looking to incorporate these newer mapping strategies into their practice?

Recorded on-site at EHRA 2026, Paris.

Editors: Jordan Rance
Videographer: David Ben-Harosh, Oliver Miles

Support: This is an independent interview produced by Radcliffe Cardiology.