Dr Isabel Deisenhofer joins us to explore how the integration of pulsed field and radiofrequency energy within a single-catheter system is reshaping ablation strategy beyond pulmonary vein isolation.

As PFA technology matures, the conversation is shifting from "does it work?" to "how do we use it best?" The emergence of dual-energy platforms — combining the safety profile of PFA with the versatility of RF — raises fundamental questions about workflow, lesion set selection, and whether a single tool can meet the demands of complex ablation cases. Dr Deisenhofer draws on her experience with the TactiFlex Duo to examine how dual-energy capability is influencing decision-making in the electrophysiology lab, from straightforward PVI to posterior wall isolation and linear lesions.

Interview Questions:

1. How has the introduction of PFA changed the way you approach ablation beyond pulmonary vein isolation — and what gaps remain?
2. When you're planning a case, what drives the decision to deploy RF versus PFA, and how does that thinking change as the procedure evolves?
3. Can you walk us through your practical experience with the TactiFlex Duo — where does the flexibility between energy modalities add the most value?
4. Posterior wall isolation and linear lesions present distinct challenges — how does a dual-energy system change your approach to these targets compared with PFA alone?
5. There's an ongoing debate about single-catheter workflows — does dual energy bring us closer to a genuine "one tool for everything" reality, or are there inherent trade-offs?
6. What would you say to electrophysiologists who are evaluating whether to incorporate dual-energy systems into their practice — what should they be weighing up?

Recorded on-site at EHRA 2026, Paris.

Editors: Jordan Rance
Videographer: David Ben-Harosh, Oliver Miles

Support: This is an independent interview produced by Radcliffe Cardiology.