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12m 35sPart 1 | Session 2 Will PFA Redefine AF Ablation Strategies in 2026?
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9m 39sPart 1 | Session 3 Redo AF Ablation: When to Go Beyond PVI?
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4m 10sPart 2 | Session 1 Stroke Management After AF Ablation
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7m 20sPart 2 | Session 2 VOLT AF IDE
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5m 53sPart 2 | Session 3 VERITAS Study: Next-Generation LAA Closure with Amulet 360
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3m 48sPart 2 | Session 4 STYLE AF Update: Venous Vascular Closure in AF Patients
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4m 50sPart 2 | Session 5 Balloon-in-Basket PFA without Propofol
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5m 58sPart 2 | Session 6 ADVENT LTO: Long-Term PFA Outcomes and AF Progression
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4m 16sPart 3 | Session 1 4 Trials That Will Change My Practice with Dr Luigi Di Biase
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5m 18sPart 3 | Session 2 AF & EP in 2026: Five Things That Will Change Daily Practice
Dr Dhanunjaya Lakkireddy (Kansas City Heart Rhythm Institute, Kansas City, US) and Dr Pasquale Santangeli (Cleveland Clinic, Cleveland, OH, US) discuss evidence-based strategies for preventing complications during complex atrial fibrillation and ventricular tachycardia ablation procedures.
This expert discussion focuses on safety considerations in high-risk electrophysiology procedures, comparing established radiofrequency (RF)-related complications with emerging risks associated with pulsed field ablation (PFA). The speakers examine how the transition from thermal to non-thermal energy changes the complication profile, with particular attention to hemolysis, myocardial injury, and coronary vasospasm. They also discuss the influence of PFA catheter design on hemolysis risk, the significance of troponin elevation and potential effects on myocardial function, and mechanisms underlying acute and delayed coronary vasospasm, highlighting the importance of long-term data from the HRS PFA registry.
Recorded on-site at AF Symposium 2026, Boston.
Editor: Jordan Rance
Videographer: David Ben-Harosh
Support: This is an independent interview produced by Radcliffe Cardiology.
Stay up to date with our video collection covering late-breaking data from AF Symposium 2026 in Boston. Don't miss our short, accessible Expert Interviews, Discussions and Highlights of the most pertinent trials.
More from this programme
Part 1
Clinical Discussions
Part 2
Expert Interviews
Faculty Biographies
Dhanunjaya Lakkireddy
Medical Director and Professor of Medicine
Dr Dhanunjaya Lakkireddy is the Medical Director at Kansas City Heart Rhythm Institute and a Professor of Medicine at the University of Missouri, Columbia. As a trained cardiologist he specialises in the research and education of electrophysiology. He is a Chairman of the ACC Electrophysiology Council as well as a member of the Program Committee in the Heart Rhythm Society.
Dr Lakkireddy has received multiple awards and recognitions, including the Professional Leader of the Year from the Asian Chamber of Commerce, Prevention Magazine Integrative Medicine Award, and Ingram's Heroes in Health Care Award.
He continues to serve as the principal investigator for clinical trials and has published more than 350 articles in the field of electrophysiology. Alongside writing articles, Dr. Lakkireddy is the Editor-in-Chief for the Journal of Atrial Fibrillation, Deputy Editor for the Journal of Interventional Electrophysiology, and editorial board member and reviewer for more than…
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